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Test tubes are seen in front of a displayed AstraZeneca logo in this illustration

Item 1 of 3 Test tubes are seen in front of a displayed AstraZeneca logo in this illustration taken, May 21, 2021. REUTERS/Dado Ruvic/Illustration/File Photo

[1/3] Test tubes are seen in front of a displayed AstraZeneca logo in this illustration taken, May 21, 2021. REUTERS/Dado Ruvic/Illustration/File Photo Purchase Licensing Rights, opens new tab

Aug 3 (Reuters) - AstraZeneca (AZN.L), opens new tab shares tumbled 7% in early ​trading on Monday following reports of ‌talks between the European pharmaceutical giant and U.S.-based Bristol Myers Squibb (BMY.N), opens new tab, baffling investors and analysts.

A person ​familiar with the matter told Reuters ​that the two held preliminary talks about ⁠a possible combination, potentially creating one of ​the world's biggest pharmaceutical companies with a ​combined value of nearly $400 billion, confirming an earlier report by the Financial Times.

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Investors and analysts questioned the ​strategic logic of the possible tie-up, ​saying Britain's biggest drugmaker had little obvious need for ‌a ⁠transformative acquisition despite potential financial benefits.

"A combination with Bristol does not make strategic or financial sense," said Markus Manns, portfolio manager ​at Union ​Investment, an ⁠AstraZeneca shareholder. "Many past mega-mergers have destroyed value and there is no ​apparent need for Astra to ​do ⁠it."

As of Friday, AstraZeneca had a market capitalization of $264.11 billion while Bristol Myers was valued ⁠at $133.41 ​billion.

Reporting by Maggie Fick ​in London, Prerna Bedi in Bengaluru; Writing by Pushkala ​Aripaka; Editing by Nivedita Bhattacharjee and Janane Venkatraman

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